Seapine Software just released an awesome upgrade to their TestTrack Pro product. If you aren't familiar with TestTrack Pro, it's a Web (and Windows client) based defect/feature tracking system. I've been using it for a few years now and think it's absolutely fantastic. They recently added a SOAP API to the product, making it *relatively* easy to access various featuers of the system programatically. In fact, Geoff Bowers (of FullAsAGoog fame even has a CFC that can access some of the system's basic functionality. If you are looking for a defect tracking system, I can highly recommend TestTrack Pro.
CFLib.org
Raymond Camden's Blog
Christian Cantrell's Blog
Sean Corfield's Blog
Nathan Dintenfass' Blog
Todd Rafferty's Blog
Steve Rittler's Blog
Cameron Childress's Blog